THE ULTIMATE GUIDE TO PKRRATING

The activated enzyme then phosphorylates its significant substrate, the translational initiation component eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to the conserved loved ones of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to distinct stimuli12, triggering the inte